Bioprocessing Technologies in Stem Cell Research

Chaired by Paula Alves, PhD
iBET - Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

Preliminary program

8.00 - 9.30am
Welcome coffee | Registration | Poster setup
9.00 - 10.00am
Early-Morning Workshop (optional)
"Introduction to Stem Cell Bioprocessing - Lineage-directed Differentiation of Human Pluripotent Stem Cells in Stirred Bioreactors"
Dr. Robert Zweigerdt (Hannover Medical School), Dr. Philipp Nold (Eppendorf AG)

9.30 - 5.30pm Scientific program, incl. lunch & coffee breaks

Session 1: Challenges in Bioprocess Engineering and Scale-Up of Stem Cell Culture

Advanced High Density Cultivation of Human Pluripotent Stem Cells by Feedback-control in Stirred Bioreactors 
Felix Manstein, MSc (Hannover Medical School)

Bioinspired Manufacturing of hPSC-derived Cardiomyocytes for Application in Cardiovascular Regenerative Medicine
Margarida Serra, PhD (iBET)

Session 2: Process Controls and Analytics

Addressing the Manufacturing Challenges of Mesenchymal Stromal Cell-based Therapies through Bioengineering
Cláudia Lobato da Silva, PhD (University of Lisbon)

Upscaling of Mesendodermal Differentiation from Human Pluripotent Stem Cells for Clinical Application
Henning Kempf, PhD (Novo Nordisk)

Session 3: Successful translation and Commercialization

Controlled and Robust Large Scale Manufacturing of hiPSC-derived Cells in Stirred-tank Bioreactors Enabling High Throughput Phenotypic Screening
Arie Reijerkerk, PhD (Ncardia)

Protocol Adaptation and Optimization to Support hPSC Expansion and Differentiation in Bioreactors under GMP-Guidelines
Michal Zimerman, MSc (Kadimastem)

Opportunity and Challenges in the Implementation of a Single-use Suspension Cell Culture Technology for the Manufacture of Difficult-to-produce Proteins
Ludwina Redtzer (BioLamina)

5.30 - 9:00pm
Conference Dinner | Poster exhibition | Poster prize (6.00pm)
 

Confirmed speakers:
Margarida Serra, PhD (iBET) 
Felix Manstein, MSc (Hannover Medical School)
Arie Reijerkerk, PhD (Ncardia)
Cláudia Lobato, PhD (University of Lisbon)
Michal Zimerman, MSc (Kadimastem)
Henning Kempf, PhD (Novo Nordisk)
Ludwina Redtzer (BioLamina)

Program and speakers are updated on a regular basis. 

 

About Paula Alves:

Paula M Alves is iBET CEO, Head of the Technology Division of ITQB NOVA, Principal Investigator at ITQB NOVA and Invited Associate Professor at FCT NOVA University.

Paula M Alves graduated in Biochemistry at the Faculdade de Ciências da Universidade de Lisboa, and holds a PhD in Biochemical Engineering from Instituto de Tecnologia Quimica Biológica da Universidade Nova de Lisboa.

Working in Animal Cell Technology since 1990, her PhD contributed to the establishment of 3D in vitro models of Brain Cells for metabolic trafficking studies. She did part of her PhD studies at the NMR Center-Sintef, Trondheim Hospital, Norway and at the NMR Laboratory of the Chemistry Department of Bremen University. She is an Independent Researcher and Principal Investigator of ITQB-NOVA (New University of Lisbon) since 2005. Since, January 2007 she is Head of the Animal Cell Technology Unit form ITQB-UNL/IBET, where she coordinates the work of five laboratories (http://tca.itqb.unl.pt). She is Invited Associate Professor at the New University of Lisbon since 2011 and CEO, IBET since March 2012.